Basic Phenergan Information

• INN (International Nonproprietary Name): Promethazine hydrochloride
• Brand names available in Australia: Phenergan
• ATC Code: R06AD02
• Forms & dosages: tablets (10mg, 25mg), elixir (1mg/mL)
• Manufacturers in Australia: sanofi-aventis australia pty ltd
• Registration status in Australia: Registered with TGA
• OTC / Rx classification: Prescription medication

Critical Warnings & Restrictions

Phenergan (Promethazine) is not without its risks, particularly for certain high-risk groups. These include the elderly, pregnant women, and individuals dealing with chronic illnesses. Using Phenergan can lead to significant concerns like respiratory depression and excessive sedation.
Close monitoring is essential, especially for elderly patients and young children, as they may be more vulnerable to these side effects.

High-Risk Groups (Elderly, Pregnancy, Chronic Illness)

When it comes to the elderly, medication reactions can often be unpredictable. Factors such as age-related organ function decline increase the risk of side effects.
For pregnant women, Phenergan falls under category C for pregnancy risk, meaning it should only be used when absolutely necessary due to potential effects on the fetus.
Patients with chronic illnesses such as liver or kidney impairment should also be cautious, as these conditions can exacerbate adverse effects.

Interaction With Activities (Driving, Workplace Safety Under Australian Law)

The sedative properties of Phenergan significantly impact tasks that require alertness, such as driving or operating heavy machinery.
Under Australian law, individuals are legally obligated to inform their employers about ongoing medication use that might affect work performance. This is particularly important in safety-sensitive roles where impairment can lead to serious accidents.

Q&A — “Can I Drive After Taking It In Australia?”

Q: Can I drive after taking Phenergan in Australia?
A: It's advised against driving after taking Phenergan due to its sedative effects, which can impair your ability to operate a vehicle safely.

Usage Basics

The International Nonproprietary Name (INN) for Phenergan is Promethazine hydrochloride. This medication is known by the brand name Phenergan in Australia, and it's available in various formulations including tablets and elixirs.
The typical strength for tablets is 10mg and 25mg, packaged in blister packs of 25 or 50. The elixir formulation consists of 1mg/mL in a 100mL bottle.

INN, Brand Names Available In Australia

It's essential to note the packaging and availability of Phenergan across Australia. Many patients seek this medication for its effectiveness in treating allergies, nausea, and motion sickness.

Legal Classification (TGA-Approved, PBS-Listed)

Legally, Phenergan is listed as a Schedule 4 medication in Australia, meaning it's available only via prescription. The Therapeutic Goods Administration (TGA) has approved Phenergan as a safe medication for various uses, and it is included in the Pharmaceutical Benefits Scheme (PBS), allowing subsidised access for eligible patients.

Dosing Guide

Understanding the dosing guidelines is crucial for effective Phenergan use. Standard doses for common conditions such as allergies and nausea are well defined.
For adults with allergic conditions, the recommended dosage ranges from 10mg to 25mg, and for sedation, it can go as high as 50mg. Pediatric dosages vary based on age and weight, typically starting at 5mg to 15mg.

Standard Regimens (PBS Reference Dosing)

Specific dosing schedules are also outlined for various indications:

• Allergic conditions: 10–25mg at night or 10mg 2–3x/day for adults
• Sedation: 25–50mg at night for adults
• Motion sickness: 25mg taken night before or one to two hours prior
• Nausea and vomiting: 25–50mg as needed, can repeat in 4–6 hours

Adjustments For Comorbidities

For those with comorbidities like renal or hepatic impairment, dose adjustments are necessary. Elderly and paediatric patients warrant special consideration, often requiring lower doses to mitigate risks.

Q&A — “What If I Miss A Dose?”

Q: What should I do if I miss a dose of Phenergan?
A: Take the missed dose as soon as you remember unless it's almost time for your next dose; do not double up.

Interaction Chart

Understanding how food and drink interacts with Phenergan is also key. Alcohol can amplify sedative effects, leading to increased drowsiness. Caffeine may also affect the efficacy of Phenergan, as it can counteract sedation.
Typical Australian dietary choices may include alcohol and high-caffeine beverages, which should be taken into account when using this medication.

Food And Drinks (Alcohol, Coffee, Australian Diet Context)

While many Australians enjoy their social beverages, it’s important to be mindful of how these can clash with taking Phenergan. Always consult with a healthcare provider for tailored advice on medication interactions.

Common Drug Conflicts

Phenergan may interact adversely with other medications, particularly other antihistamines and central nervous system depressants. Always consult a healthcare professional before combining therapies to avoid potential complications.

User Reports & Trends

Feedback from patients in Australia indicates that Phenergan is often effective for motion sickness and allergic reactions. However, many report drowsiness as a significant side effect. Platforms like ProductReview often reflect common themes in patient experiences with this medication.

Access & Purchase Options

Phenergan is easily accessible at major pharmacy chains such as Chemist Warehouse, Priceline, and TerryWhite Chemmart, where it is priced competitively.
For those seeking convenience, online pharmacies are becoming increasingly popular, offering telehealth consultations that allow for easy access to prescriptions, especially for those in rural areas.

Mechanism & Pharmacology

Simplified explanation

Phenergan, containing promethazine hydrochloride, operates primarily as an antihistamine. Its mechanism of action involves blocking H1 histamine receptors. This blockage is key in alleviating symptoms associated with allergic reactions, nausea, and motion sickness. Moreover, Phenergan also possesses sedative properties, making it useful for preoperative sedation. Users often find relief from discomfort caused by allergies, while also experiencing drowsiness, which can be beneficial in specific situations where calming effects are desired.

Clinical terms

Antihistamines like Phenergan play a critical role in managing allergic responses within the respiratory system. By targeting histamine receptors, they hinder the release of various allergic agents, leading to decreased symptoms such as sneezing, itching, and nasal congestion. In the context of the Australian health system, Phenergan is frequently prescribed based on patient experiences and clinical guidelines established by regulatory bodies like the TGA. Additionally, awareness of the potential side effects is integral to patient safety.

Indications & Off-Label Uses

Approved indications by TGA

The Therapeutic Goods Administration (TGA) endorses Phenergan for several medical indications. These include the treatment of allergies, specifically hay fever and urticaria, as well as managing nausea and vomiting in various settings, including post-operative care. Preoperative sedation is another approved use, where patients are administered Phenergan to ensure calmness and facilitate procedures. Such guidelines ensure that health professionals follow recommended practices in user care.

Off-label uses in Australian clinical practice

In addition to its approved uses, healthcare professionals in Australia often rely on Phenergan for off-label purposes. Common applications include the management of motion sickness, where patients take the medication before travel to mitigate symptoms. It’s also used to address sleep disturbances, helping those who struggle with insomnia by promoting drowsiness. The adaptability of Phenergan in various clinical contexts highlights its utility among practitioners.

Key Clinical Findings

Recent clinical studies from 2022 to 2025 have offered insights into the effectiveness and safety of Phenergan. Research shows that it remains a commonly prescribed antihistamine in Australia, with a stable trend in its use for allergic reactions and nausea. Findings suggest that patient outcomes are generally positive, with significant relief from symptoms observed. However, concerns about sedation and drowsiness persist, prompting calls for careful patient monitoring. Prescribing patterns indicate a preference for Phenergan for specific conditions, while clinicians remain cautious about its sedative effects, particularly in elderly populations.

Alternatives Matrix

PBS-listed alternatives comparison table

Pros and cons checklist

• Pros: Effective antihistamine, provides sedation helpful in pre-surgery settings.
• Cons: Can cause drowsiness, risk of respiratory depression in children.

Common Questions

Many healthcare professionals receive questions concerning Phenergan's effects and usage. A prevalent inquiry revolves around its efficacy in treating allergies and nausea. Patients often ask about its sedative effects and whether it’s safe to operate machinery after consuming the medication. Additionally, concerns about potential side effects prompt discussions about best practices for dosage, especially among younger populations and the elderly.

Suggested Visual Content

Visual content can enhance understanding of Phenergan's role in healthcare. Infographics detailing its pricing on the PBS (Pharmaceutical Benefits Scheme) would offer insights into its affordability. Another useful visual could be a map of Australian pharmacy networks, showcasing the accessibility and availability of Phenergan. Such resources would benefit patients, aiding their decision-making process regarding treatment options.

Registration & Regulation

When looking into medication safety, the approval process through Australia’s Therapeutic Goods Administration (TGA) stands as a vital benchmark. The TGA evaluates medications like Phenergan to ensure they meet stringent safety, quality, and efficacy standards before they hit the market. Patients can rest easy knowing a rigorous assessment process takes place.

TGA approval

The pathway to approval includes comprehensive clinical trials assessing the drug's effects on various conditions. Phenergan, with its active ingredient promethazine hydrochloride, has undergone this scrutiny. Only after confirming its therapeutic benefits and potential risks does the TGA grant it an AUST R status, paving the way for legal availability in pharmacies.

PBS subsidy details

Phenergan is included in the Pharmaceutical Benefits Scheme (PBS), which is crucial for Australian patients seeking subsidised medication. To access these subsidies, individuals typically must meet certain criteria, such as demonstrating a genuine clinical need. This system makes it more affordable for those who need relief from allergies, nausea, or insomnia.

Storage & Handling

Correct storage and handling of Phenergan are essential for maintaining its effectiveness, especially given Australia’s varied climate. Hot and humid conditions can negatively impact medications, highlighting the importance of understanding storage protocols.

Household storage in Australian climate

When storing Phenergan at home, keep these key conditions in mind:

• Store below 30°C (86°F).
• Avoid direct sunlight; opt for a cool, dark area.
• Always keep it in its original packaging to guard against moisture.

Given the risk of humidity in some regions, ensuring a stable environment can safeguard the medication's potency over time.

Cold-chain handling for pharmacies

Pharmacies play a crucial role in the cold-chain management of Phenergan formulations. Maintaining proper storage conditions protects the drug's integrity. Adhering to strict cold-chain protocols ensures that pharmacists only dispense medications that are still effective and safe for use.

Guidelines for Proper Use

Using Phenergan effectively involves seeking proper guidance. Australian pharmacists are well-trained to provide relevant information and support for patients who require this medication.

Australian pharmacist counselling style

Pharmacists in Australia adopt a patient-centric approach when dispensing Phenergan. They generally cover important aspects such as:

• Instructions on usage and dosage.
• Potential side effects to watch for.
• Interactions with other medications.

This practice ensures that patients feel informed and empowered about their medication choices.

Patient advice from PBS and national health authorities

Health authorities in Australia provide essential advice on using Phenergan responsibly. Key takeaways include:

• Consult a healthcare professional if unsure about dosage.
• Be aware of drowsiness as a common side effect.
• Avoid driving or operating heavy machinery until you understand how Phenergan affects you.

By following these guidelines, users can maximise the benefits while minimising risks associated with their treatment.

Delivery Information