Basic Plaquenil Information

• INN (International Nonproprietary Name): Hydroxychloroquine
• Brand names available in Australia: Plaquenil
• ATC Code: P01BA02
• Forms & dosages: Film-coated tablets, typically 200mg
• Manufacturers in Australia: Sanofi, generic forms
• Registration status in Australia: Prescription only
• OTC/Rx classification: RX only

Critical Warnings & Restrictions

Before starting treatment with Plaquenil, consulting a healthcare provider is essential. This medication, primarily used to treat malaria and autoimmune disorders like rheumatoid arthritis and lupus, can have significant side effects. It's vital to obtain a thorough medical evaluation to mitigate risks.

Various warnings associated with the usage of Plaquenil must be acknowledged. Severe allergic reactions, toxicity, and other side effects are possible. Patients should be particularly vigilant about any unusual symptoms. Immediate medical attention is required if signs of an allergic reaction occur, including rash, itching, or breathing difficulties.

High-Risk Groups

Certain groups may experience heightened risks when taking Plaquenil:

• Elderly: The elderly are at an increased risk of retinal toxicity and other side effects. Continuous monitoring and regular eye examinations are highly recommended.
• Pregnancy and Breastfeeding: According to TGA guidelines, the use of Plaquenil during pregnancy should only occur if the benefits outweigh the potential risks. Caution is advised for breastfeeding mothers as the drug can pass into breast milk, possibly affecting the infant's health.

Interaction with Activities

Patients taking Plaquenil should exercise caution with certain activities. Driving or operating heavy machinery is particularly concerning due to potential side effects like dizziness, blurred vision, or fatigue. Always consult your healthcare provider to evaluate your fitness for these activities while on medication.

Q&A – Can I Drive After Taking It in Australia?

Yes, but you should consult with your healthcare provider.

Usage Basics

For those navigating the complexities of autoimmune diseases or certain types of malaria, understanding the fundamentals of Plaquenil—an antimalarial and immunosuppressant—is essential.

Brand Names Available in Australia

In Australia, the most recognised brand of plaquenil is Plaquenil, available in 200 mg film-coated tablets. This formulation is commonly prescribed for conditions such as rheumatoid arthritis and systemic lupus erythematosus.

Additionally, several generic alternatives may be found under the name Hydroxychloroquine. Other international brands include:

• Dolquine - prevalent in France and Germany.
• Quensyl - exclusive to France.
• Hydroxychloroquine Winthrop - also marketed in various European countries.

The availability of Plaquenil in both branded and generic forms provides patients and healthcare providers with options tailored to individual needs and preferences.

Legal Classification

Plaquenil is classified as a prescription medication in Australia. It is fully approved by the Therapeutic Goods Administration (TGA) and is listed under the Pharmaceutical Benefits Scheme (PBS), ensuring patients have access to it at a subsidised cost.

This approval underscores Plaquenil’s efficacy and safety profile, crucial for its use in various therapeutic settings.

For more detailed information about its PBS listing, visit PBS Australia's official site.

Dosing Guide

When it comes to administering plaquenil, proper dosing is crucial for ensuring effectiveness and safety. Referencing the PBS dosing guidelines helps both patients and healthcare providers navigate the appropriate regimens.

Standard Regimens

For maximum effectiveness, plaquenil dosing varies based on conditions:

• **Malaria prophylaxis**: Adults take 400 mg weekly; children’s doses are 6.5 mg/kg, not exceeding 400 mg per week.
• **Malaria treatment**: Adults start with 800 mg, followed by 400 mg at 6, 24, and 48 hours. Pediatric doses are based on weight, capped at 2 g.
• **Rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE)**: Adults generally require 200-400 mg daily, while children get 3-7 mg/kg/day (up to a maximum of 400 mg).
• **Juvenile idiopathic arthritis**: Recommended doses range from 3-6 mg/kg/day, often under specialist oversight.

Adjustments for Comorbidities

In patients with comorbid conditions, dosage adjustments become necessary:

• Children: Doses should be strictly weight-based, and ophthalmologic assessments are essential.
• Elderly: Administer with caution due to increased sensitivity – watch for potential retinal toxicity and heart issues.
• Liver or Kidney Impairments: Lower doses may be required. Regular monitoring through blood tests and eye exams is recommended.

Q&A — What if I miss a dose?

If a dose is missed, it's advisable to take it as soon as you remember. However, if it’s close to the time for your next scheduled dose, skip the missed one. Avoid doubling up on doses.

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